General
Preferred name
ALW-II-49-7
Synonyms
5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide ()
P&D ID
PD004842
CAS
1135219-23-6
Tags
available
probe
drug candidate
Drug Status
experimental
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
Gray Laboratory Probes
High-quality chemical probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ALW-II-49-7 is a selective EphB2 kinase inhibitor with an EC50 value of 40 nM in cell[1].
PRICE 225
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION ALW-II-49-7 is a selective and potent inhibitor of EphB2 kinase, with an EC50 value of 40 nM in cell. (TargetMol Bioactive Compound Library)
Compound Sets
8
Chemical Probes.org
alw-ii-49-7
CZ-OPENSCREEN Bioactive Library
DrugBank
DB07970
Gray Laboratory Probes
High-quality chemical probes
PD004842
LINCS compound set
10003-101
MedChem Express Bioactive Compound Library
HY-18833
TargetMol Bioactive Compound Library
T67736
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
414.13
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
4.5
TPSA
97.11
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Target
DDR2
DDR1
Ephrin Receptor
DDR2, DDR1
EphB2
Target class
Kinase, Kinase
Target subclass
Tyrosine kinase, Tyrosine kinase
Source data